Back to Search
Start Over
Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2015 Oct 09; Vol. 16 (10), pp. 23784-822. Date of Electronic Publication: 2015 Oct 09. - Publication Year :
- 2015
-
Abstract
- Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 16
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 26473828
- Full Text :
- https://doi.org/10.3390/ijms161023784