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The performance of Dynamic Spectral Imaging colposcopy depends on indication for referrals.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2015 Dec; Vol. 139 (3), pp. 452-7. Date of Electronic Publication: 2015 Oct 22. - Publication Year :
- 2015
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Abstract
- OBJECTIVE. A previous study has shown that Dynamic Spectral Imaging (DSI) colposcopy increases the sensitivity of the colposcopic examination in women referred with abnormal cytology. In this study we have reanalyzed the performance of DSI and conventional colposcopy for new referral conditions and for low-grade cytology referrals versus high-grade cytology referrals. METHOD. Data from a previous validation trial was used to assess the performance of DSI in different cytology groups:Women referred with BMD (borderline and mild dyskaryosis) cytology and women referred with NBMD cytology either hrHPV positive or negative were separately analyzed. Furthermore, we tried to assess the clinical performance by appropriate filtering of patients to replicate two different referral strategies. RESULTS. The sensitivity of DSI and conventional colposcopy to detect CIN2+ lesions in women referred with BMD cytology is 82% and 44% respectively (p= 0.001) and in the NBMD group 77% and 64% respectively (p= 0.24). If the two techniques are combined the sensitivity is 85%.When the conditions of new screening strategies are applied DSI colposcopy has a higher sensitivity to detect CIN2+ than conventional colposcopy. Findings are similar when CIN3+ is used as a threshold. CONCLUSION. We found that in most cases DSI colposcopy has a higher sensitivity than conventional colposcopy, even when referral criteria are changed. Unlike conventional colposcopy, the sensitivity of colposcopy with DSI in low-grade cytology referrals was found similar to the sensitivity in high-grade cytology referrals. This suggests that a baseline colposcopy sensitivity may be possible with the adjunctive use of the DSI map, irrespective of referral cytology.
- Subjects :
- Acetic Acid
Adolescent
Adult
Female
Humans
Middle Aged
Papillomaviridae isolation & purification
Prospective Studies
Referral and Consultation
Sensitivity and Specificity
Uterine Cervical Neoplasms pathology
Uterine Cervical Neoplasms virology
Young Adult
Uterine Cervical Dysplasia pathology
Uterine Cervical Dysplasia virology
Cervix Uteri pathology
Colposcopy methods
Early Detection of Cancer methods
Optical Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 139
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26475960
- Full Text :
- https://doi.org/10.1016/j.ygyno.2015.10.009