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Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated With and Without Catheter Ablation.
- Source :
-
Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2015 Dec; Vol. 8 (6), pp. 1465-71. Date of Electronic Publication: 2015 Oct 19. - Publication Year :
- 2015
-
Abstract
- Background: There are a paucity of data about the long-term natural history of adult Wolff-Parkinson-White syndrome (WPW) patients in regard to risk of mortality and atrial fibrillation. We sought to describe the long-term outcomes of WPW patients and ascertain the impact of ablation on the natural history.<br />Methods and Results: Three groups of patients were studied: 2 WPW populations (ablation: 872, no ablation: 1461) and a 1:5 control population (n=11 175). Long-term mortality and atrial fibrillation rates were determined. The average follow-up for the WPW group was 7.9±5.9 (median: 6.9) years and was similar between the ablation and nonablation groups. Death rates were similar between the WPW group versus the control group (hazard ratio, 0.96; 95% confidence interval, 0.83-1.11; P=0.56). Nonablated WPW patients had a higher long-term death risk compared with ablated WPW patients (hazard ratio, 2.10; 95% confidence interval: 1.50-20.93; P<0.0001). Incident atrial fibrillation risk was higher in the WPW group compared with the control population (hazard ratio, 1.55; 95% confidence interval, 1.29-1.87; P<0.0001). Nonablated WPW patients had lower risk than ablated patients (hazard ratio, 0.39; 95% confidence interval, 0.28-0.53; P<0.0001).<br />Conclusions: Long-term mortality rates in WPW patients are low and similar to an age-matched and gender-matched control population. WPW patients that underwent the multifactorial process of ablation had a lower mortality compared to nonablated WPW patients. Atrial fibrillation rates are high long-term, and ablation does not reduce this risk.<br /> (© 2015 American Heart Association, Inc.)
- Subjects :
- Adult
Age Factors
Aged
Atrial Fibrillation epidemiology
Female
Humans
Idaho epidemiology
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Proportional Hazards Models
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Utah epidemiology
Wolff-Parkinson-White Syndrome diagnosis
Wolff-Parkinson-White Syndrome mortality
Wolff-Parkinson-White Syndrome physiopathology
Young Adult
Catheter Ablation
Wolff-Parkinson-White Syndrome surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1941-3084
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Circulation. Arrhythmia and electrophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 26480930
- Full Text :
- https://doi.org/10.1161/CIRCEP.115.003013