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TCEA3 Attenuates Gastric Cancer Growth by Apoptosis Induction.
- Source :
-
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2015 Oct 26; Vol. 21, pp. 3241-6. Date of Electronic Publication: 2015 Oct 26. - Publication Year :
- 2015
-
Abstract
- Background: The aim of this study was to investigate and interpret the expression level and potential function of TCEA3 in gastric cancer.<br />Material and Methods: qRT-PCR was used to determine the expression level of TCEA3 in gastric cancer tissues. Pearson χ2 test was performed to clarify the correlation between TCEA3 expression and patients' clinicopathologic characteristics. Biological function of TCEA3 was tested by proliferation assay and colony formation assay. Flow cytometry was used to study the potential function of TCEA3 in apoptosis induction.<br />Results: TCEA3 expression was significantly downregulated in gastric cancer tissues compared with paired normal tissues. Poor prognoses were observed in the low TCEA3 expression group of patients in contrast to the high TCEA3 expression group. Functionally, upregulation of TCEA3 inhibited gastric cancer cell proliferation and colony formation. We also found that TCEA3 may attenuate cell growth through apoptosis induction.<br />Conclusions: Our findings suggest that TCEA3 attenuates the proliferation and induces apoptosis of gastric cancer cells.
- Subjects :
- Aged
Cell Line, Tumor
Cell Proliferation
DNA, Complementary metabolism
Female
Flow Cytometry
Humans
Male
Middle Aged
Prognosis
Real-Time Polymerase Chain Reaction
Apoptosis
Gene Expression Regulation, Neoplastic
Stomach Neoplasms metabolism
Stomach Neoplasms pathology
Transcriptional Elongation Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1643-3750
- Volume :
- 21
- Database :
- MEDLINE
- Journal :
- Medical science monitor : international medical journal of experimental and clinical research
- Publication Type :
- Academic Journal
- Accession number :
- 26498664
- Full Text :
- https://doi.org/10.12659/msm.895860