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Estimation of the Antirelapse Efficacy of Tafenoquine, Using Plasmodium vivax Genotyping.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2016 Mar 01; Vol. 213 (5), pp. 794-9. Date of Electronic Publication: 2015 Oct 23. - Publication Year :
- 2016
-
Abstract
- Unlabelled: Prevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled phase 2b study in Peru, India, Thailand, and Brazil allowed determination of genetically heterologous or homologous P. vivax infection recurrence following receipt of chloroquine plus one of 4 doses of tafenoquine (50, 100, 300, or 600 mg) or chloroquine plus primaquine, compared with receipt of chloroquine alone. The antihypnozoite efficacy of tafenoquine was evident as a reduction in homologous recurrences of P. vivax infection as drug doses were increased. No clear dose-response pattern was evident for heterologous recurrences of P. vivax infection. Rates of homologous recurrence of P. vivax infection appear to be clinically useful for comparing drug efficacy for the prevention of P. vivax infection relapse.<br />Clinical Trials Registration: NCT01376167.<br /> (© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Subjects :
- Aminoquinolines administration & dosage
Antimalarials administration & dosage
Chloroquine administration & dosage
Chloroquine therapeutic use
Dose-Response Relationship, Drug
Double-Blind Method
Genotype
Humans
Primaquine administration & dosage
Primaquine therapeutic use
Aminoquinolines therapeutic use
Antimalarials therapeutic use
Malaria, Vivax drug therapy
Plasmodium vivax genetics
Secondary Prevention
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 213
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26500351
- Full Text :
- https://doi.org/10.1093/infdis/jiv508