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Urinary IP-10, MCP-1, NGAL, Cystatin-C, and KIM-1 Levels in Prenatally Diagnosed Unilateral Hydronephrosis: The Search for an Ideal Biomarker.
- Source :
-
Urology [Urology] 2016 Jan; Vol. 87, pp. 185-92. Date of Electronic Publication: 2015 Oct 23. - Publication Year :
- 2016
-
Abstract
- Objective: To investigate the urinary interferon gamma-induced protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), cystatin-C, and kidney injury molecule-1 (KIM-1) levels in the management of children with prenatally diagnosed unilateral hydronephrosis.<br />Materials and Methods: Twenty-seven children with antenatally diagnosed hydronephrosis were enrolled into the study. The controls consisted of 9 healthy children (6 boys, 3 girls; mean age: 41.77 ± 5.30 months). Thirteen children (9 boys, 4 girls; mean age: 48.46 ± 21.11 months) underwent pyeloplasty on follow-up; the remaining 14 (13 boys, 1 girl; mean age: 36.57 ± 14.02 months) were followed up after being diagnosed as having nonobstructive dilatation (NOD). The urinary marker levels were measured in the pyeloplasty, the NOD, and the control groups.<br />Results: The preoperative concentrations of IP-10, MCP-1, NGAL, and KIM-1 were significantly higher in the pyeloplasty group than in the control group (P = .024, P = .002, P = .032, P = .001, respectively). The urinary IP-10 and MCP-1 levels were also significantly higher in the pyeloplasty group than in the NOD group (P = .038, P = .037, respectively). There was no significant difference between the pyeloplasty group and the NOD group regarding urinary NGAL and KIM-1. In the pyeloplasty group, urinary marker levels except cystatin-C were significantly decreased in the postoperative period.<br />Conclusion: A decrease in levels of IP-10, MCP-1, NGAL, and KIM-1 after pyeloplasty may be used as a predictor of surgical outcome. Additionally, IP-10 and MCP-1 were superior to NGAL and KIM-1 in predicting who required surgery.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Biomarkers urine
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Hepatitis A Virus Cellular Receptor 1
Humans
Hydronephrosis diagnosis
Hydronephrosis surgery
Infant
Lipocalin-2
Male
Preoperative Period
Prospective Studies
Receptors, Virus
Plastic Surgery Procedures
Urinalysis
Urologic Surgical Procedures methods
Acute-Phase Proteins urine
Chemokine CCL2 urine
Chemokine CXCL10 urine
Cystatin C urine
Hydronephrosis urine
Lipocalins urine
Membrane Glycoproteins urine
Prenatal Diagnosis methods
Proto-Oncogene Proteins urine
Subjects
Details
- Language :
- English
- ISSN :
- 1527-9995
- Volume :
- 87
- Database :
- MEDLINE
- Journal :
- Urology
- Publication Type :
- Academic Journal
- Accession number :
- 26505835
- Full Text :
- https://doi.org/10.1016/j.urology.2015.09.007