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Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study.

Authors :
Orlow I
Reiner AS
Thomas NE
Roy P
Kanetsky PA
Luo L
Paine S
Armstrong BK
Kricker A
Marrett LD
Rosso S
Zanetti R
Gruber SB
Anton-Culver H
Gallagher RP
Dwyer T
Busam K
Begg CB
Berwick M
Source :
Carcinogenesis [Carcinogenesis] 2016 Jan; Vol. 37 (1), pp. 30-8. Date of Electronic Publication: 2015 Oct 31.
Publication Year :
2016

Abstract

Factors known to affect melanoma survival include age at presentation, sex and tumor characteristics. Polymorphisms also appear to modulate survival following diagnosis. Result from other studies suggest that vitamin D receptor (VDR) polymorphisms (SNPs) impact survival in patients with glioma, renal cell carcinoma, lung, breast, prostate and other cancers; however, a comprehensive study of VDR polymorphisms and melanoma-specific survival is lacking. We aimed to investigate whether VDR genetic variation influences survival in patients with cutaneous melanoma. The analysis involved 3566 incident single and multiple primary melanoma cases enrolled in the international population-based Genes, Environment, and Melanoma Study. Melanoma-specific survival outcomes were calculated for each of 38 VDR SNPs using a competing risk analysis after adjustment for covariates. There were 254 (7.1%) deaths due to melanoma during the median 7.6 years follow-up period. VDR SNPs rs7299460, rs3782905, rs2239182, rs12370156, rs2238140, rs7305032, rs1544410 (BsmI) and rs731236 (TaqI) each had a statistically significant (trend P values < 0.05) association with melanoma-specific survival in multivariate analysis. One functional SNP (rs2239182) remained significant after adjustment for multiple testing using the Monte Carlo method. None of the SNPs associated with survival were significantly associated with Breslow thickness, ulceration or mitosis. These results suggest that the VDR gene may influence survival from melanoma, although the mechanism by which VDR exerts its effect does not seem driven by tumor aggressiveness. Further investigations are needed to confirm our results and to understand the relationship between VDR and survival in the combined context of tumor and host characteristics.<br /> (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1460-2180
Volume :
37
Issue :
1
Database :
MEDLINE
Journal :
Carcinogenesis
Publication Type :
Academic Journal
Accession number :
26521212
Full Text :
https://doi.org/10.1093/carcin/bgv157