Modulation of nuclear PI-PLCbeta1 during cell differentiation.

Authors :: Cocco L
Manzoli L
Faenza I
Ramazzotti G
Yang YR
McCubrey JA
Suh PG
Follo MY
Source :: Advances in biological regulation [Adv Biol Regul] 2016 Jan; Vol. 60, pp. 1-5. Date of Electronic Publication: 2015 Oct 26.
Publication Year :: 2016
Abstract: PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to differentiate, as well as in human cells obtained from myotonic dystrophy. Also in the case of osteogenic differentiation there is a specific induction of PI-PLCbeta1, but in this case the role of PI-PLCbeta1 seems to be independent from Cyclin D3, so that a different mechanism could be involved. As for the hematopoietic system, PI-PLCbeta1 has a peculiar behavior: it increases during myeloid differentiation and decreases during erythroid differentiation, thus confirming the role of PI-PLCbeta1 as a modulator of hematopoiesis.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)