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Should patients with laryngeal small cell neuroendocrine carcinoma receive prophylactic cranial irradiation?
- Source :
-
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2016 Oct; Vol. 273 (10), pp. 2925-30. Date of Electronic Publication: 2015 Nov 03. - Publication Year :
- 2016
-
Abstract
- While small cell neuroendocrine carcinomas (SCNCs) most often arise in the lung, extrapulmonary SCNCs arise in a variety of locations-including the head and neck region. In particular, laryngeal SCNCs-while rare tumors-are nevertheless recognized as distinct lesions. The rarity of laryngeal SCNC gives rise to two distinct difficulties: first (particularly with small biopsy specimens), laryngeal SCNC can be difficult to diagnose by routine light microscopy; second, limited experience with these tumors can make the crafting of a treatment plan for individual patients difficult. As regards the first problem, pathologic diagnosis is greatly enhanced by the application of immunohistochemistry. The second problem-crafting a successful treatment strategy-presents a much larger difficulty. It is tempting to extrapolate from experience with the (more common) pulmonary SCNC in search of a strategy applicable to laryngeal SCNC; such an extrapolation, however, may not be uniformly successful. In particular, while a combination of radiation therapy and chemotherapy appears to be as valuable in the treatment of extrapulmonary as it is in the treatment of pulmonary SCNC, prophylactic cranial irradiation (PCI)-which has enjoyed some success in the treatment of some patients with pulmonary SCNC-does not appear to have similar utility in patients with laryngeal SCNC. Accordingly, the use of PCI does not appear to have a role to play at this point in time in the treatment of patients with laryngeal SCNC.
- Subjects :
- Brain Neoplasms secondary
Carcinoma, Neuroendocrine pathology
Carcinoma, Neuroendocrine secondary
Carcinoma, Small Cell pathology
Carcinoma, Small Cell secondary
Humans
Immunohistochemistry
Male
Middle Aged
Brain Neoplasms prevention & control
Carcinoma, Neuroendocrine prevention & control
Carcinoma, Small Cell prevention & control
Cranial Irradiation
Laryngeal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1434-4726
- Volume :
- 273
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 26530293
- Full Text :
- https://doi.org/10.1007/s00405-015-3799-y