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IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Dec 15; Vol. 195 (12), pp. 5707-17. Date of Electronic Publication: 2015 Nov 04. - Publication Year :
- 2015
-
Abstract
- Intracellular infections, such as those caused by the protozoan parasite Leishmania donovani, a causative agent of visceral leishmaniasis (VL), require a potent host proinflammatory response for control. IL-17 has emerged as an important proinflammatory cytokine required for limiting growth of both extracellular and intracellular pathogens. However, there are conflicting reports on the exact roles for IL-17 during parasitic infections and limited knowledge about cellular sources and the immune pathways it modulates. We examined the role of IL-17 in an experimental model of VL caused by infection of C57BL/6 mice with L. donovani and identified an early suppressive role for IL-17 in the liver that limited control of parasite growth. IL-17-producing γδ T cells recruited to the liver in the first week of infection were the critical source of IL-17 in this model, and CCR2(+) inflammatory monocytes were an important target for the suppressive effects of IL-17. Improved parasite control was independent of NO generation, but associated with maintenance of superoxide dismutase mRNA expression in the absence of IL-17 in the liver. Thus, we have identified a novel inhibitory function for IL-17 in parasitic infection, and our results demonstrate important interactions among γδ T cells, monocytes, and infected macrophages in the liver that can determine the outcome of parasitic infection.<br /> (Copyright © 2015 by The American Association of Immunologists, Inc.)
- Subjects :
- Animals
Disease Models, Animal
Humans
Immunosuppression Therapy
Leishmania donovani growth & development
Liver parasitology
Mice
Mice, Inbred C57BL
Monocytes immunology
Monocytes parasitology
Receptors, Antigen, T-Cell, gamma-delta metabolism
Receptors, CCR2 metabolism
Superoxide Dismutase metabolism
T-Lymphocytes parasitology
Interleukin-17 metabolism
Leishmania donovani immunology
Leishmaniasis, Visceral immunology
Liver immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 195
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 26538396
- Full Text :
- https://doi.org/10.4049/jimmunol.1501046