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Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2O3 Phase.

Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2O3 Phase.

Authors :
Casterou G
Collière V
Lecante P
Coppel Y
Eliat PA
Gauffre F
Kahn ML
Source :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2015 Dec 14; Vol. 21 (51), pp. 18855-61. Date of Electronic Publication: 2015 Nov 06.
Publication Year :
2015

Abstract

Pure and highly crystalline γ-Fe2O3 nanocrystals (NCs) are obtained when hydrolysis and oxidation of a Fe(II) organometallic precursor are performed in successive steps. Their synthesis in pure alkylamine leads to NCs of about 6 nm. In aqueous solutions of poly(vinyl)pyrrolidone, such pristine NCs form aggregates of about 150 nm that exhibit a high transversal relaxivity (r2 =466 mM(-1) s(-1)) about four times higher than that of a commercial Feridex magnetic resonance imaging (MRI) contrast agent. Consequently, they provide a significant decrease in the NMR signal at very short echo time (8 ms), which is of paramount importance in clinical practice because of the reduced duration of MRI measurements.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1521-3765
Volume :
21
Issue :
51
Database :
MEDLINE
Journal :
Chemistry (Weinheim an der Bergstrasse, Germany)
Publication Type :
Academic Journal
Accession number :
26542051
Full Text :
https://doi.org/10.1002/chem.201502905