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Speciation of precious metal anti-cancer complexes by NMR spectroscopy.
- Source :
-
Drug discovery today. Technologies [Drug Discov Today Technol] 2015 Sep; Vol. 16, pp. 7-15. Date of Electronic Publication: 2015 Sep 11. - Publication Year :
- 2015
-
Abstract
- Understanding the mechanism of action of anti-cancer agents is of paramount importance for drug development. NMR spectroscopy can provide insights into the kinetics and thermodynamics of the binding of metallodrugs to biomolecules. NMR is most sensitive for highly abundant I=1/2 nuclei with large magnetic moments. Polarization transfer can enhance NMR signals of insensitive nuclei at physiologically-relevant concentrations. This paper reviews NMR methods for speciation of precious metal anti-cancer complexes, including platinum-group and gold-based anti-cancer agents. Examples of NMR studies involving interactions with DNA and proteins in particular are highlighted.<br /> (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
Coordination Complexes therapeutic use
Gold chemistry
Gold therapeutic use
Humans
Metals, Heavy therapeutic use
Platinum chemistry
Platinum therapeutic use
Rhodium chemistry
Rhodium therapeutic use
Antineoplastic Agents chemistry
Coordination Complexes chemistry
Magnetic Resonance Spectroscopy methods
Metals, Heavy chemistry
Neoplasms diagnosis
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1740-6749
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- Drug discovery today. Technologies
- Publication Type :
- Academic Journal
- Accession number :
- 26547416
- Full Text :
- https://doi.org/10.1016/j.ddtec.2015.08.002