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2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Dec 15; Vol. 25 (24), pp. 5694-8. Date of Electronic Publication: 2015 Nov 02. - Publication Year :
- 2015
-
Abstract
- A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Bacterial Proteins analysis
Benzothiazoles metabolism
Benzoxazoles metabolism
Gram-Negative Bacteria enzymology
Gram-Positive Bacteria enzymology
Nitroreductases analysis
Spectrometry, Fluorescence
Substrate Specificity
Bacterial Proteins metabolism
Benzothiazoles chemistry
Benzoxazoles chemistry
Fluorescent Dyes chemistry
Nitroreductases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 25
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 26547691
- Full Text :
- https://doi.org/10.1016/j.bmcl.2015.10.099