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Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise.
- Source :
-
Thrombosis research [Thromb Res] 2016 Jan; Vol. 137, pp. 92-96. Date of Electronic Publication: 2015 Nov 07. - Publication Year :
- 2016
-
Abstract
- Background: The aim of our study was to evaluate the effect of programmed physical activity and a single exercise test on the number of CD309+ circulating endothelial progenitor cell (EPC) and their relation to the variation in plasma levels of VEGF in chronic coronary patients.<br />Methods: 21 patients <75 years with chronic stable coronary artery disease were included. All patients underwent exercise myocardial perfusion SPECT. Then, participants were divided into two groups: one group (11 patients) underwent cardiac rehabilitation program and the other (10 patients) continued with the standard treatment. Blood samples were obtained at baseline, 30 min after exercise ended and at one and three months during follow-up.<br />Results: VEGF values decreased significantly after exercise SPECT test. After one month, there was a significant increase in VEGF levels compared to those measured immediately after exercise. All patients showed a decrease in the values of EPC at 1 and 3-month follow-up. There was an inverse and statistically significant relation between change of EPC and VEGF between the baseline and 1 month.<br />Conclusions: The increase of VEGF at 1-month, with respect to baseline values correlated with decreased levels of EPC. This association was independent of the onset of ischemia in the perfusion study.
- Subjects :
- Adaptation, Physiological
Aged
Cell Line
Cell Proliferation
Cell Survival
Coronary Artery Disease physiopathology
Exercise Test
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neovascularization, Physiologic physiology
Coronary Artery Disease pathology
Coronary Artery Disease therapy
Endothelial Progenitor Cells metabolism
Endothelial Progenitor Cells pathology
Exercise Therapy methods
Vascular Endothelial Growth Factor A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-2472
- Volume :
- 137
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 26577258
- Full Text :
- https://doi.org/10.1016/j.thromres.2015.11.012