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Subgroup characteristics of insular low-grade glioma based on clinical and molecular analysis of 42 cases.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2016 Feb; Vol. 126 (3), pp. 499-507. Date of Electronic Publication: 2015 Nov 19. - Publication Year :
- 2016
-
Abstract
- Although the classification of insular glioma has been established based on the anatomical location in order to facilitate personalized surgical resection, the diagnosis based on anatomical and functional characteristics becomes more complex when insular tumors extend into either the frontobasal brain region and/or the temporal lobe, as part of the limbic system. Moreover, prognosis of insular tumor resection is still controversial. Further analysis of subgroup characteristics of insular grade II gliomas based on clinical and molecular analysis is required to reliably determine patients' survival rates. In this retrospective study 20 purely insular grade II gliomas patients and 22 paralimbic grade II gliomas that involved frontal and/or temporal lobes were compared with regard to epidemiological and clinical characteristics. The molecular profiles including Isocitrate dehydrogenase 1 (IDH1), telomerase reverse transcriptase (TERT) promoter, and P53 mutations, 1p19q co-deletion were analyzed, and microRNA profiles were assessed by microarray and bioinformatics analysis. Purely insular grade II gliomas displayed a high frequency of IDH1 mutations with favorable outcome. IDH1 mutated paralimbic glioma shared many parameters with the purely insular glioma in respect to growth patterns, survival, and microRNA profile, but differed significantly from the IDH1 wild type paralimbic gliomas. Our findings suggest that IDH1 mutations can define subpopulations of insular gliomas with distinct disease entities regardless of tumor extension patterns. These findings could be useful to develop a customized treatment strategy for insular glioma patients.
- Subjects :
- Adult
Aged
Brain Neoplasms genetics
Female
Follow-Up Studies
Glioma genetics
Humans
Isocitrate Dehydrogenase genetics
Magnetic Resonance Imaging
Male
Middle Aged
Mutation genetics
Neoplasm Grading
Neoplasm Invasiveness
Prognosis
Promoter Regions, Genetic genetics
Retrospective Studies
Survival Rate
Telomerase genetics
Tumor Suppressor Protein p53 genetics
Young Adult
Biomarkers, Tumor genetics
Brain Neoplasms classification
Brain Neoplasms pathology
Glioma classification
Glioma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7373
- Volume :
- 126
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26586262
- Full Text :
- https://doi.org/10.1007/s11060-015-1989-5