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A protocol for amide bond formation with electron deficient amines and sterically hindered substrates.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2016 Jan 14; Vol. 14 (2), pp. 430-433. - Publication Year :
- 2016
-
Abstract
- A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26586516
- Full Text :
- https://doi.org/10.1039/c5ob02129d