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Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of Their Anti-Alzheimer's Disease Activities.
- Source :
-
Organic letters [Org Lett] 2015 Dec 04; Vol. 17 (23), pp. 5910-3. Date of Electronic Publication: 2015 Nov 20. - Publication Year :
- 2015
-
Abstract
- As an extension of previously conducted studies on developing an anti-Alzheimer's disease agent, denosomin (1-deoxy-24-norsominone, an artificial inducer of neurite elongation), derivatives were designed and synthesized based on the hypothesis that our denosomin would exhibit axonal extension activity via a 1,25D(3)-membrane-associated, rapid response steroid-binding protein (1,25D(3)-MARRS) pathway. The biological assay revealed that the hybridization of characteristic δ-lactone in denosomin and the triene moiety in VD(3) was effective to enhance the nerve re-extension activity in amyloid β (Aβ)-damaged neurons.
- Subjects :
- Amyloid beta-Peptides metabolism
Cell Membrane metabolism
Cholecalciferol chemistry
Cholecalciferol pharmacology
Dehydroepiandrosterone chemical synthesis
Dehydroepiandrosterone chemistry
Dehydroepiandrosterone pharmacology
Molecular Structure
Neurons pathology
Alzheimer Disease drug therapy
Cholecalciferol chemical synthesis
Dehydroepiandrosterone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 17
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 26588585
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b03138