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Development of epilepsy after ischaemic stroke.
- Source :
-
The Lancet. Neurology [Lancet Neurol] 2016 Feb; Vol. 15 (2), pp. 185-197. Date of Electronic Publication: 2015 Nov 17. - Publication Year :
- 2016
-
Abstract
- For about 30% of patients with epilepsy the cause is unknown. Even in patients with a known risk factor for epilepsy, such as ischaemic stroke, only a subpopulation of patients develops epilepsy. Factors that contribute to the risk for epileptogenesis in a given individual generally remain unknown. Studies in the past decade on epilepsy in patients with ischaemic stroke suggest that, in addition to the primary ischaemic injury, existing difficult-to-detect microscale changes in blood vessels and white matter present as epileptogenic pathologies. Injury severity, location and type of pathological changes, genetic factors, and pre-injury and post-injury exposure to non-genetic factors (ie, the exposome) can divide patients with ischaemic stroke into different endophenotypes with a variable risk for epileptogenesis. These data provide guidance for animal modelling of post-stroke epilepsy, and for laboratory experiments to explore with increased specificity the molecular 'mechanisms, biomarkers, and treatment targets of post-stroke epilepsy in different circumstances, with the aim of modifying epileptogenesis after ischaemic stroke in individual patients without compromising recovery.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Humans
Brain Ischemia complications
Epilepsy etiology
Stroke complications
Subjects
Details
- Language :
- English
- ISSN :
- 1474-4465
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Lancet. Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 26597090
- Full Text :
- https://doi.org/10.1016/S1474-4422(15)00248-3