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IgA as therapeutic antibody.
- Source :
-
Molecular immunology [Mol Immunol] 2015 Nov; Vol. 68 (1), pp. 35-9. - Publication Year :
- 2015
-
Abstract
- This review is focused on the promises of IgA as a new therapeutic antibody. For more than 30 years IgG molecules have been used in the clinic in the fields of oncology, hematology, auto immune diseases and infections. However, IgA might be a good alternative, since it recruits different effector cells, i.e. polymorphonuclear cells or neutrophils, but can also activate monocytes and macrophages. The present knowledge, but also future direction for IgA- based drugs are discussed.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antigens, CD20 genetics
Antigens, CD20 immunology
B-Lymphocytes drug effects
B-Lymphocytes immunology
B-Lymphocytes pathology
Gene Expression
Humans
Immunoglobulin A genetics
Immunoglobulin A immunology
Immunoglobulin G genetics
Immunoglobulin G immunology
Lymphocyte Depletion
Macrophages immunology
Macrophages pathology
Mice
Monocytes immunology
Monocytes pathology
Neoplasms genetics
Neoplasms immunology
Neoplasms pathology
Neutrophils immunology
Neutrophils pathology
Antineoplastic Agents therapeutic use
Immunization, Passive methods
Immunoglobulin A therapeutic use
Neoplasms therapy
Rituximab therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26597204
- Full Text :
- https://doi.org/10.1016/j.molimm.2015.09.005