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Sulfotanone, a new alkyl sulfonic acid derivative from Streptomyces sp. IFM 11694 with TRAIL resistance-overcoming activity.
- Source :
-
Journal of natural medicines [J Nat Med] 2016 Apr; Vol. 70 (2), pp. 266-70. Date of Electronic Publication: 2015 Nov 25. - Publication Year :
- 2016
-
Abstract
- One new alkyl sulfonic acid derivative, sulfotanone (1), and the known panosialin wA (2) were isolated from the methanolic extract of mycelium of Streptomyces sp. 11694. The structure of the new compound (1) was established by a combination of spectroscopic techniques, including HRESIMS, IR, 1D and 2D NMR measurements. Compound 1 (40 µM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance in human gastric adenocarcinoma cell lines.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Benzene Derivatives isolation & purification
Biological Products chemistry
Biological Products isolation & purification
Biological Products pharmacology
Biological Products therapeutic use
Cell Line, Tumor
Drug Synergism
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Sulfonic Acids chemistry
Sulfonic Acids isolation & purification
Sulfonic Acids pharmacology
Adenocarcinoma drug therapy
Antineoplastic Agents therapeutic use
Drug Resistance drug effects
Stomach Neoplasms drug therapy
Streptomyces chemistry
Sulfonic Acids therapeutic use
TNF-Related Apoptosis-Inducing Ligand therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1861-0293
- Volume :
- 70
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of natural medicines
- Publication Type :
- Academic Journal
- Accession number :
- 26607379
- Full Text :
- https://doi.org/10.1007/s11418-015-0951-3