Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid Songorine.

Authors :: Zyuz'kov GN
Zhdanov VV
Udut EV
Miroshnichenko LA
Chaikovskii AV
Simanina EV
Udut VV
Stavrova LA
Polyakova TY
Minakova MY
Trifonova OY
Gridneva TD
Dygai AM
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Nov; Vol. 160 (1), pp. 64-7. Date of Electronic Publication: 2015 Nov 25.
Publication Year :: 2015
Abstract: The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of realization of the growth potential of the mesenchymal precursor cells by alkaloid songorine were examined in vitro. Specific inhibitors of JNK and p53 enhanced stimulation of fibroblast colony/cluster formation and proliferative activity of mesenchymal precursor cells. Under these conditions, more pronounced effects were observed with early precursors of fibroblast CFU and in both cases were accompanied by a decrease in differentiation index of progenitor elements.

Subjects :: Animals
Apoptosis drug effects
Benzothiazoles pharmacology
Cells, Cultured
Colony-Forming Units Assay
JNK Mitogen-Activated Protein Kinases antagonists & inhibitors
MAP Kinase Signaling System physiology
Male
Mesenchymal Stem Cells metabolism
Mice
Mice, Inbred CBA
Protein Kinase Inhibitors pharmacology
Toluene analogs & derivatives
Toluene pharmacology
Tumor Suppressor Protein p53 antagonists & inhibitors
Alkaloids pharmacology
MAP Kinase Signaling System drug effects
Mesenchymal Stem Cells drug effects
Tumor Suppressor Protein p53 physiology

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