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Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins.
- Source :
-
Developmental cell [Dev Cell] 2015 Nov 23; Vol. 35 (4), pp. 401-2. - Publication Year :
- 2015
-
Abstract
- Inhibition of GSK3 by Wnt signaling stabilizes many cellular proteins, but proof that this effect is independent of β-catenin-mediated transcription is lacking. Koch, Acebron, and colleagues (2015) now demonstrate that transcriptionally silent mammalian sperm require Wnt signaling via exosomes to prevent protein degradation during their lengthy travels through the epididymis.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-1551
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 26609954
- Full Text :
- https://doi.org/10.1016/j.devcel.2015.11.009