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Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Dec 15; Vol. 112 (50), pp. 15378-83. Date of Electronic Publication: 2015 Nov 30. - Publication Year :
- 2015
-
Abstract
- Animals in nature are continually challenged by periods of feast and famine as resources inevitably fluctuate, and must allocate somatic reserves for reproduction to abate evolutionary pressures. We identify an age-dependent lipid homeostasis pathway in Caenorhabditis elegans that regulates the mobilization of lipids from the soma to the germline, which supports fecundity but at the cost of survival in nutrient-poor and oxidative stress environments. This trade-off is responsive to the levels of dietary carbohydrates and organismal oleic acid and is coupled to activation of the cytoprotective transcription factor SKN-1 in both laboratory-derived and natural isolates of C. elegans. The homeostatic balance of lipid stores between the somatic and germ cells is mediated by arachidonic acid (omega-6) and eicosapentaenoic acid (omega-3) precursors of eicosanoid signaling molecules. Our results describe a mechanism for resource reallocation within intact animals that influences reproductive fitness at the cost of somatic resilience.
- Subjects :
- Aging drug effects
Animals
Caenorhabditis elegans drug effects
Caenorhabditis elegans Proteins metabolism
Germ Cells drug effects
Oleic Acid deficiency
Reproduction drug effects
Survival Analysis
Vitellogenesis drug effects
Caenorhabditis elegans metabolism
Fatty Acids, Omega-3 pharmacology
Fatty Acids, Omega-6 pharmacology
Food
Germ Cells metabolism
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 112
- Issue :
- 50
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 26621724
- Full Text :
- https://doi.org/10.1073/pnas.1514012112