Synthesis and fluorescent study of 5-phenyl furocoumarin derivatives as vasodilatory agents.

Authors :: Wang C
Wang T
Huang L
Lu W
Zhang J
He H
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Jan 15; Vol. 26 (2), pp. 640-644. Date of Electronic Publication: 2015 Nov 17.
Publication Year :: 2016
Abstract: Two series of 5-phenyl furocoumarin derivatives were designed and prepared based on our previous research. All new compounds were characterized by (1)H NMR, (13)C NMR and mass spectra. Furthermore, they were screened for their vasodilatory activity on the mesenteric artery of Sprague-Dawley rats, and they all presented with moderate vasodilatory activity. Fluorescent properties of the target compounds were tested in methanol. The fluorescence variation of 4a was investigated in different solvents, various pH and the migration time was determined. All results indicated that this type of fluorescent compound can be used as vasodilatory agents and probes simultaneously after further structural modifications.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Fluorescence
Furocoumarins chemical synthesis
Magnetic Resonance Spectroscopy
Mesenteric Arteries physiology
Models, Molecular
Rats, Sprague-Dawley
Spectrometry, Fluorescence
Structure-Activity Relationship
Vasodilator Agents chemical synthesis
Furocoumarins chemistry
Furocoumarins pharmacology
Mesenteric Arteries drug effects
Vasodilator Agents chemistry
Vasodilator Agents pharmacology

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