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INTRAVITREAL CONBERCEPT (KH902) FOR SURGICAL TREATMENT OF SEVERE PROLIFERATIVE DIABETIC RETINOPATHY.
- Source :
-
Retina (Philadelphia, Pa.) [Retina] 2016 May; Vol. 36 (5), pp. 938-43. - Publication Year :
- 2016
-
Abstract
- Purpose: To evaluate the role, safety, and effectiveness of intravitreal conbercept (KH902) injections as an adjunct to vitrectomy in the management of severe proliferative diabetic retinopathy.<br />Methods: A randomized controlled trial was performed on 36 eyes of 36 patients affected by vitreous hemorrhage and tractional retinal detachment, which occurred as a consequence of active proliferative diabetic retinopathy. The patients were randomly assigned to two groups. The patients in one of the groups received an intravitreal injection of conbercept in the inferior temporal sector 4 mm from the sclerocorneal limbus with a sterile technique 1 week before vitrectomy.<br />Results: In the group without conbercept, intraoperative bleeding occurred in 14 patients (77.8%), and in five of these cases, bleeding was significant. The use of endodiathermy was necessary in 8 patients (44.4%). In 3 patients (16.6%), iatrogenic retinal breaks occurred, and in 1 patient (5.5%), a relaxing retinotomy was performed. Endotamponade with silicone oil was performed in 12 patients (66.6%). In the group treated with conbercept, intraoperative bleeding occurred in 2 cases (11.1%). The use of endodiathermy was necessary in 1 patient (5.5%). No patients experienced iatrogenic breaks or relaxing retinotomy during the surgery. Endotamponade with silicone oil was performed in 2 patients (11.1%).<br />Conclusion: Preoperative intravitreal injection of conbercept could reduce the chances of intraoperative bleeding, which are beneficial in the management of proliferative diabetic retinopathy.
- Subjects :
- Combined Modality Therapy
Diabetic Retinopathy drug therapy
Diabetic Retinopathy physiopathology
Diabetic Retinopathy surgery
Diathermy
Endotamponade
Humans
Intravitreal Injections
Prospective Studies
Retinal Detachment drug therapy
Retinal Detachment physiopathology
Retinal Detachment surgery
Retinal Detachment therapy
Retinal Neovascularization drug therapy
Retinal Neovascularization physiopathology
Retinal Neovascularization surgery
Silicone Oils administration & dosage
Vascular Endothelial Growth Factor A antagonists & inhibitors
Visual Acuity physiology
Vitreous Hemorrhage drug therapy
Vitreous Hemorrhage physiopathology
Vitreous Hemorrhage surgery
Vitreous Hemorrhage therapy
Angiogenesis Inhibitors therapeutic use
Diabetic Retinopathy therapy
Recombinant Fusion Proteins therapeutic use
Retinal Neovascularization therapy
Vitrectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2864
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Retina (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 26630313
- Full Text :
- https://doi.org/10.1097/IAE.0000000000000900