Back to Search
Start Over
Signal integration by Ca(2+) regulates intestinal stem-cell activity.
- Source :
-
Nature [Nature] 2015 Dec 10; Vol. 528 (7581), pp. 212-7. Date of Electronic Publication: 2015 Dec 02. - Publication Year :
- 2015
-
Abstract
- Somatic stem cells maintain tissue homeostasis by dynamically adjusting proliferation and differentiation in response to stress and metabolic cues. Here we identify Ca(2+) signalling as a central regulator of intestinal stem cell (ISC) activity in Drosophila. We show that dietary L-glutamate stimulates ISC division and gut growth. The metabotropic glutamate receptor (mGluR) is required in ISCs for this response, and for an associated modulation of cytosolic Ca(2+) oscillations that results in sustained high cytosolic Ca(2+) concentrations. High cytosolic Ca(2+) concentrations induce ISC proliferation by regulating Calcineurin and CREB-regulated transcriptional co-activator (Crtc). In response to a wide range of dietary and stress stimuli, ISCs reversibly transition between Ca(2+) oscillation states that represent poised or activated modes of proliferation, respectively. We propose that the dynamic regulation of intracellular Ca(2+) levels allows effective integration of diverse mitogenic signals in ISCs to adapt their proliferative activity to the needs of the tissue.
- Subjects :
- Animals
Cell Proliferation drug effects
Cytosol chemistry
Diet
Drosophila melanogaster drug effects
Drosophila melanogaster metabolism
Glutamic Acid pharmacology
Intestines cytology
Receptors, Metabotropic Glutamate metabolism
Stem Cells metabolism
Calcium metabolism
Drosophila melanogaster cytology
Signal Transduction
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 528
- Issue :
- 7581
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 26633624
- Full Text :
- https://doi.org/10.1038/nature16170