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Multicenter Phase II Study of Nedaplatin and Irinotecan for Patients with Squamous Cell Carcinoma of the Lung: Thoracic Oncology Research Group 0910.
- Source :
-
Anticancer research [Anticancer Res] 2015 Dec; Vol. 35 (12), pp. 6705-11. - Publication Year :
- 2015
-
Abstract
- Squamous cell carcinoma (SCC) of the lung is moderately responsive to anticancer drugs, but no specific chemotherapy regimens have yet been established. We conducted a multicenter phase II study of nedaplatin (NP) and irinotecan (CPT) for SCC of the lung. Fifty patients underwent 4 to 6 cycles of chemotherapy comprising of NP at 100 mg/m(2) on day 1 and CPT at 60 mg/m(2) on days 1 and 8 every 4 weeks. Twenty-seven patients received 4 to 6 cycles of chemotherapy (median=4 cycles). Major toxicities included neutropenia (46.0%), grade 3 or 4 anorexia (22.0%), febrile neutropenia (16.0%), diarrhea (12.0%), hyponatremia (12.0%), grade 4 anemia (10.0%), thrombocytopenia (10.0%) and infection (10.0%). There were no treatment-related deaths. One patient achieved a complete response and 16 a partial response, with an overall response rate of 34.0%. The median survival time was 11.8 months (95% CI=8.3-15.8 months) and the 2-year survival rate was 22.0%. In conclusion, the NP and CPT regimen is not recommend for further evaluation for patients with advanced SCC of the lung.<br /> (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Subjects :
- Adult
Aged
Antineoplastic Agents administration & dosage
Camptothecin administration & dosage
Camptothecin therapeutic use
Carcinoma, Squamous Cell pathology
Female
Humans
Irinotecan
Lung Neoplasms pathology
Male
Middle Aged
Organoplatinum Compounds administration & dosage
Antineoplastic Agents therapeutic use
Camptothecin analogs & derivatives
Carcinoma, Squamous Cell drug therapy
Lung Neoplasms drug therapy
Organoplatinum Compounds therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 35
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 26637886