Back to Search
Start Over
Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis.
- Source :
-
Pancreas [Pancreas] 2016 Feb; Vol. 45 (2), pp. 311-6. - Publication Year :
- 2016
-
Abstract
- Objectives: While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years.<br />Methods: We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age- and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC.<br />Results: Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose- and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09).<br />Conclusions: The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.
- Subjects :
- Adenocarcinoma etiology
Adenocarcinoma physiopathology
Age Factors
Age of Onset
Alcohol Drinking adverse effects
Case-Control Studies
Diabetes Mellitus physiopathology
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Obesity complications
Odds Ratio
Pancreatic Neoplasms etiology
Pancreatic Neoplasms physiopathology
Pancreatitis complications
Risk Factors
Smoking adverse effects
Adenocarcinoma diagnosis
Pancreatic Neoplasms diagnosis
Risk Assessment methods
Risk Assessment statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 45
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 26646264
- Full Text :
- https://doi.org/10.1097/MPA.0000000000000392