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Lewis Acid Mediated Vinylogous Additions of Enol Nucleophiles into an α,β-Unsaturated Platinum Carbene.

Lewis Acid Mediated Vinylogous Additions of Enol Nucleophiles into an α,β-Unsaturated Platinum Carbene.

Authors :
Allegretti PA
Huynh K
Ozumerzifon TJ
Ferreira EM
Source :
Organic letters [Org Lett] 2016 Jan 04; Vol. 18 (1), pp. 64-7. Date of Electronic Publication: 2015 Dec 14.
Publication Year :
2016

Abstract

A variety of substituted indoles and benzofurans are accessed via a platinum catalyzed annulation and vinylogous addition of enol nucleophiles. Several β-dicarbonyl compounds participate in the reaction, as do α-nitro and α-cyano carbonyl species. Subjecting the indole products to acidic conditions results in the formation of fused heterocycles.

Details

Language :
English
ISSN :
1523-7052
Volume :
18
Issue :
1
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
26652926
Full Text :
https://doi.org/10.1021/acs.orglett.5b03246