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Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration.
- Source :
-
The Journal of hospital infection [J Hosp Infect] 2016 Feb; Vol. 92 (2), pp. 199-202. Date of Electronic Publication: 2015 Nov 06. - Publication Year :
- 2016
-
Abstract
- Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.<br /> (Copyright © 2015. Published by Elsevier Ltd.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Injections, Intraventricular
Male
Middle Aged
Retrospective Studies
Anti-Bacterial Agents analysis
Anti-Bacterial Agents pharmacokinetics
Cerebrospinal Fluid chemistry
Drug Monitoring
Meningitis, Bacterial drug therapy
Vancomycin analysis
Vancomycin pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2939
- Volume :
- 92
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of hospital infection
- Publication Type :
- Academic Journal
- Accession number :
- 26654472
- Full Text :
- https://doi.org/10.1016/j.jhin.2015.10.017