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Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Oral Squamous Cell Carcinoma (OSCC): Prognostic Value and Clinico-Pathological Implications.
- Source :
-
International journal of medical sciences [Int J Med Sci] 2015 Nov 01; Vol. 12 (12), pp. 937-45. Date of Electronic Publication: 2015 Nov 01 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Background: Collagen Triple Helix Repeat Containing 1 (CTHRC1) is a protein often found to be over-expressed in various types of human cancers. However, correlation between CTHRC1 expression level with clinico-pathological characteristics and prognosis in oral cancer remains unclear. Therefore, this study aimed to determine mRNA and protein expression of CTHRC1 in oral squamous cell carcinoma (OSCC) and to evaluate the clinical and prognostic impact of CTHRC1 in OSCC.<br />Methods: In this study, mRNA and protein expression of CTHRC1 in OSCCs were determined by quantitative PCR and immunohistochemistry, respectively. The association between CTHRC1 and clinico-pathological parameters were evaluated by univariate and multivariate binary logistic regression analyses. Correlation between CTHRC1 protein expressions with survival were analysed using Kaplan-Meier and Cox regression models.<br />Results: Current study demonstrated CTHRC1 was significantly overexpressed at the mRNA level in OSCC. Univariate analyses indicated a high-expression of CTHRC1 that was significantly associated with advanced stage pTNM staging, tumour size ≥ 4 cm and positive lymph node metastasis (LNM). However, only positive LNM remained significant after adjusting with other confounder factors in multivariate logistic regression analyses. Kaplan-Meier survival analyses and Cox model demonstrated that patients with high-expression of CTHRC1 protein were associated with poor prognosis and is an independent prognostic factor in OSCC.<br />Conclusion: This study indicated that over-expression of CTHRC1 potentially as an independent predictor for positive LNM and poor prognosis in OSCC.
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell pathology
Case-Control Studies
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphatic Metastasis genetics
Lymphatic Metastasis pathology
Male
Middle Aged
Mouth Neoplasms pathology
Prognosis
Proportional Hazards Models
RNA, Messenger genetics
RNA, Messenger metabolism
RNA, Neoplasm genetics
RNA, Neoplasm metabolism
Real-Time Polymerase Chain Reaction
Up-Regulation
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell metabolism
Extracellular Matrix Proteins genetics
Extracellular Matrix Proteins metabolism
Mouth Neoplasms genetics
Mouth Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1449-1907
- Volume :
- 12
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 26664254
- Full Text :
- https://doi.org/10.7150/ijms.11605