Getting Tumor Dendritic Cells to Engage the Dead.

The immunogenic effects of chemotherapy rely on effective activation of dendritic cells to present antigen to tumor-specific T cells. However, the signals that govern how dendritic cells seek out dying cancer cells to initiate this process are poorly understood. A recent study by Vacchelli et al. provides important insight.
(Copyright © 2015 Elsevier Inc. All rights reserved.)