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Regulatory T cell memory.
- Source :
-
Nature reviews. Immunology [Nat Rev Immunol] 2016 Feb; Vol. 16 (2), pp. 90-101. Date of Electronic Publication: 2015 Dec 21. - Publication Year :
- 2016
-
Abstract
- Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using prime-challenge models of infection. However, recent work has also identified persistently expanded populations of antigen-specific regulatory T cells that protect against aberrant immune responses. In this Review, we consider the parallels between memory effector T cells and memory regulatory T cells, along with the functional implications of regulatory memory in autoimmunity, antimicrobial host defence and maternal-fetal tolerance. In addition, we discuss emerging evidence for regulatory T cell memory in humans and key unanswered questions in this rapidly evolving field.<br />Competing Interests: statement The authors declare no competing interests.
Details
- Language :
- English
- ISSN :
- 1474-1741
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature reviews. Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26688349
- Full Text :
- https://doi.org/10.1038/nri.2015.1