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Relationship between pre-treatment nutritional status, serum glutamine, arginine levels and clinicopathological features in Taiwan colorectal cancer patients.
- Source :
-
Asia Pacific journal of clinical nutrition [Asia Pac J Clin Nutr] 2015; Vol. 24 (4), pp. 598-604. - Publication Year :
- 2015
-
Abstract
- Background and Objectives: To examine the relationship between malnutrition criteria, serum glutamine and arginine concentrations, and clinicopathological features in Taiwan colorectal cancer patients.<br />Methods and Study Design: Three malnutrition criteria (body weight loss>5% over past 6 months, body mass index (BMI)<18.5 kg/m2, and hypoalbuminemia) and serum levels of glutamine and arginine were measured in 164 colorectal patients. Malnutrition status and serum glutamine and arginine concentrations were tested for their association with each other, as well as with the clinicopathological variables.<br />Results: Of the 164 patients, 38 (23.5%) had body weight loss, 19 (11.9%) had low BMI, and 57 (35.8%) had hypoalbuminemia. The univariate analysis showed hypoalbuminemia was correlated with advanced tumour stage, lower concentrations of glutamine, higher C-reactive protein level, and progression-free survival rate. Univariate analysis also showed glutamine levels were lower in advanced tumour stage, but arginine levels were not associated with any clinicopathologic variables. Neither the nutrition criteria used in this study nor glutamine and arginine levels were correlated with hospital stay or progression-free survival rate in multivariate analysis.<br />Conclusions: Different nutrition assessment criteria produced different malnutrition rates in colorectal cancer patients; however, pre-treatment malnourished status and low serum glutamine and arginine concentrations were not correlated with hospital stay and progressionfree survival rate.
- Subjects :
- Aged
Aged, 80 and over
Body Mass Index
C-Reactive Protein analysis
Colorectal Neoplasms pathology
Disease-Free Survival
Female
Humans
Hypoalbuminemia
Length of Stay
Male
Malnutrition blood
Middle Aged
Neoplasm Staging
Nutrition Assessment
Taiwan
Weight Loss
Arginine blood
Colorectal Neoplasms surgery
Glutamine blood
Malnutrition complications
Nutritional Status
Subjects
Details
- Language :
- English
- ISSN :
- 0964-7058
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Asia Pacific journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 26693743
- Full Text :
- https://doi.org/10.6133/apjcn.2015.24.4.23