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Research Advances on Pathways of Nickel-Induced Apoptosis.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2015 Dec 23; Vol. 17 (1). Date of Electronic Publication: 2015 Dec 23. - Publication Year :
- 2015
-
Abstract
- High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity.
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 26703593
- Full Text :
- https://doi.org/10.3390/ijms17010010