Increasing demonstration of angiogenic markers in skin neoplastic lesions.

Authors :: de Almeida CM
de Jesus SF
Poswar Fde O
Gomes ES
Fraga CA
Farias LC
Santos SH
Feltenberger JD
de Paula AM
Guimarães AL
Source :: Pathology, research and practice [Pathol Res Pract] 2016 Feb; Vol. 212 (2), pp. 101-5. Date of Electronic Publication: 2015 Dec 08.
Publication Year :: 2016
Abstract: Background: Skin cancer represents the most common worldwide malignancy. Angiogenesis is an important factor in tumor growth and metastasis. Given these facts, the purpose of the current study was to compare the levels of angiogenic proteins in the context of the most common malignant and premalignant skin lesions.<br />Methods: Immunohistochemistry of CD31, HIF1A, VEGFR1 and VEGFR2 was performed in basal cell carcinoma (BCC), actinic keratosis (AK) and squamous cell carcinoma of the skin (SCCS).<br />Results: SCCS presented with increased levels of HIF1A, VEGFR1 and VEGFR2 in comparison to AK. In addition, SCCS also demonstrated increased levels of HIF1A to BCCLR or BCCHR. BCC presented with more vessels than AK. However, no correlation was observed among CD31, HIF1A, VEGFR1 and VEGFR2.<br />Conclusions: SCCS presented with higher levels of HIF1A, VEGFR1 and VEGFR2, while BCC demonstrated an increased number of vessels in relation to AK. These data suggest that antiangiogenic therapy might be useful for skin cancer treatment.<br /> (Copyright © 2015 Elsevier GmbH. All rights reserved.)