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Evaluation of switching from intravenous to subcutaneous formulation of tocilizumab in patients with rheumatoid arthritis.
- Source :
-
Modern rheumatology [Mod Rheumatol] 2016 Sep; Vol. 26 (5), pp. 662-6. Date of Electronic Publication: 2016 Feb 16. - Publication Year :
- 2016
-
Abstract
- Objective: To evaluate the efficacy of switching the route from intravenous tocilizumab (TCZ) infusion (TCZ-IV) to subcutaneous TCZ injection (TCZ-SC) in a real-world setting through a comparison of the clinical response.<br />Methods: Fifty-eight rheumatoid arthritis (RA) patients, for whom TCZ-SC was initiated following TCZ-IV between June 2013 and August 2014, were consecutively enrolled. Disease activity score (DAS)28-ESR, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were examined at baseline and after switching from TCZ-IV to TCZ-SC for 3 months. We investigated whether body weight and body mass index (BMI) affected the efficacy of TCZ-SC.<br />Results: Most of the patients had achieved remission or low disease activity at baseline (77.6% examined by DAS28). Fifty-seven patients (98%) continued the TCZ-SC treatment, and the disease activity was well controlled after 3 months. ΔDAS28 tended to be worsened after switching to TCZ-SC in the high-body-weight groups (≥60 kg) as compared with the groups with body weight <60 kg, although no statistical significance was found. BMI did not affect the efficacy of TCZ-SC.<br />Conclusions: Caution should be exercised in the high-body-weight subjects, but these data indicate that TCZ-SC maintains the favorable RA disease activity established using TCZ-IV.
- Subjects :
- Adult
Aged
Antibodies, Monoclonal, Humanized therapeutic use
Antirheumatic Agents therapeutic use
Female
Humans
Infusions, Intravenous
Injections, Subcutaneous
Male
Middle Aged
Treatment Outcome
Antibodies, Monoclonal, Humanized administration & dosage
Antirheumatic Agents administration & dosage
Arthritis, Rheumatoid drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7609
- Volume :
- 26
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Modern rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 26708444
- Full Text :
- https://doi.org/10.3109/14397595.2015.1129692