Back to Search
Start Over
Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?
- Source :
-
World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2016 Jan; Vol. 32 (1), pp. 5. Date of Electronic Publication: 2015 Dec 28. - Publication Year :
- 2016
-
Abstract
- We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from the same base, they exhibit considerably different antimicrobial mechanisms. In the presence of Ca(2+) ions the MIC and MBC values of ammonium salt increased 100-fold, suggesting that Ca(2+) ions can successfully impede the membrane Ca(2+) ions exchange required for ammonium salt incorporation. In contrast, in the presence of quaternary phosphonium salt, the artificial capsular-like material was formed around the cells and the filamentous and chain-like growth of the cells was observed suggesting the disruption of the cell division mechanisms. Altogether, both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis) and Escherichia coli considerably, while demonstrated nearly no effect against Klebsiella pneumoniae and Pseudomonas aeruginosa. We suggest that due to their effects on distinct and likely complementary targets the derivatives of pyridoxine represent potentially perspective antibacterials with complicated adaptation and thus with lower risk of drug resistance development.
- Subjects :
- Anti-Bacterial Agents chemistry
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Microscopy, Confocal
Microscopy, Electron, Scanning
Microscopy, Fluorescence
Organophosphorus Compounds chemistry
Pyridoxine chemistry
Quaternary Ammonium Compounds chemistry
Anti-Bacterial Agents pharmacology
Organophosphorus Compounds pharmacology
Pyridoxine pharmacology
Quaternary Ammonium Compounds pharmacology
Staphylococcal Infections drug therapy
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0972
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of microbiology & biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 26712620
- Full Text :
- https://doi.org/10.1007/s11274-015-1969-0