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Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2015 Dec 21; Vol. 21 (47), pp. 13352-9. - Publication Year :
- 2015
-
Abstract
- Aim: To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease (NERD) patients.<br />Methods: Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impedance - pH on rabeprazole. The symptom index (SI) was considered to be positive if ≥ 50%, and proximal reflux episodes were determined when reflux reached 15 cm above the proximal margin of the lower esophageal sphincter.<br />Results: In 14 (40%) SI-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms was significantly more frequent in proximal reflux episodes (46.7%) than in distal ones (5.7%) (P < 0.001). With liquid acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes (38.5%) and distal ones (20.5%) (NS). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent (31.0%) than in distal reflux ones (3.3%) (P < 0.001). With mixed liquid-gas acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes (29.4%) and distal ones (14.3%) (NS).<br />Conclusion: The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor associated with reflux perception in SI-positive patients on proton pump inhibitor therapy.
- Subjects :
- Adult
Aged
Asian People
Drug Administration Schedule
Electric Impedance
Esophageal pH Monitoring
Female
Gastroesophageal Reflux diagnosis
Gastroesophageal Reflux ethnology
Gastroesophageal Reflux physiopathology
Heartburn diagnosis
Heartburn ethnology
Heartburn physiopathology
Humans
Japan
Male
Middle Aged
Perception
Time Factors
Young Adult
Drug Resistance
Esophagus physiopathology
Gastroesophageal Reflux drug therapy
Heartburn drug therapy
Proton Pump Inhibitors administration & dosage
Rabeprazole administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 21
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 26715820
- Full Text :
- https://doi.org/10.3748/wjg.v21.i47.13352