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Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma.
- Source :
-
Oncotarget [Oncotarget] 2016 Jan 26; Vol. 7 (4), pp. 4036-47. - Publication Year :
- 2016
-
Abstract
- The interplay between tumor microenvironment and cancer that causes chemoresistance remains unclear. By analyzing public available microarray datasets, we identified that periostin (POSTN) was overexpressed in cancer stroma in epithelial ovarian cancer (EOC) patients. Immunohistochemistry analysis showed overexpression of stromal POSTN is a powerful independent poor prognostic predictor for EOC patients. Furthermore, patients with high levels of stromal POSTN tend to have higher percentage of cisplatin resistance compared to those with low levels of stromal POSTN. Moreover, we found POSTN treatment can induce cisplatin resistant and activate AKT pathway in A2780 cells in vitro. Inhibition of AKT activity by AKT inhibitor MK-2206 abolished POSTN-induced AKT activation and cisplatin resistance in vitro. Taken together, we found high POSTN expression in cancer microenvironment is correlated with poor prognosis in EOC patients and associated with platinum resistance. The effect of POSTN in cancer stroma cells may activate AKT pathway in tumor and AKT inhibitor can be beneficial to augment the efficacy of existing cancer therapeutics.
- Subjects :
- Adenocarcinoma, Clear Cell drug therapy
Adenocarcinoma, Clear Cell metabolism
Adenocarcinoma, Clear Cell pathology
Adenocarcinoma, Mucinous drug therapy
Adenocarcinoma, Mucinous metabolism
Adenocarcinoma, Mucinous pathology
Antineoplastic Agents pharmacology
Apoptosis drug effects
Blotting, Western
Cell Proliferation drug effects
Cystadenocarcinoma, Serous drug therapy
Cystadenocarcinoma, Serous metabolism
Cystadenocarcinoma, Serous pathology
Endometrial Neoplasms drug therapy
Endometrial Neoplasms metabolism
Endometrial Neoplasms pathology
Female
Follow-Up Studies
Humans
Immunoenzyme Techniques
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local drug therapy
Neoplasm Recurrence, Local metabolism
Ovarian Neoplasms drug therapy
Ovarian Neoplasms metabolism
Prognosis
Survival Rate
Tumor Cells, Cultured
Tumor Microenvironment drug effects
Biomarkers, Tumor metabolism
Cell Adhesion Molecules metabolism
Cisplatin pharmacology
Drug Resistance, Neoplasm
Neoplasm Recurrence, Local pathology
Ovarian Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 26716408
- Full Text :
- https://doi.org/10.18632/oncotarget.6700