LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer.

Authors :: Jiang F
Ma S
Xue Y
Hou J
Zhang Y
Source :: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 Jan 22; Vol. 469 (4), pp. 985-92. Date of Electronic Publication: 2015 Dec 22.
Publication Year :: 2016
Abstract: Lactate dehydrogenase-A(LDH-A) is an important rate-limiting enzyme in the Warburg effect. Survival analysis indicated poor clinical outcomes in MIBC with high LDH-A expression. The results of in vitro experiment indicated that LDH-A promotes MIBC cells proliferation, invasion and migration. The positive relationship between LDH-A expression and CSC/EMT markers was confirmed both in invasive bladder cell line and in 136 MIBC specimens. Thus, we conclude that LDH-A may be a promising target for MIBC.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)

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