[Histoplasmosis, serologic follow-up].

This paper reports the positive results obtained in the sera of 70 patients with histoplasmosis, the clinical presentation of the disease, and the possibilities for an appropriate follow-up of the clinical course of these patients by means of titers of the sera taken during the persistence of the signs and symptoms of the disease and following its resolution. The most frequent clinical presentation was acute pulmonary disease and the single m precipitation band was found in a higher number of sera than the association of h and m bands. The authors report a case diagnosed as acute pulmonary histoplasmosis, that 9 months after a clinically and serologically negative continuum showed again precipitation bands and Histoplasma capsulatum was isolated from his oral mucosa lesions. The significance of serologic follow-up in patients with histoplasmosis until their total negativization and the feasibility of this follow-up by means of the titering of sera by the counterimmune electrophoresis technique.