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Synthesis, structure and in vitro cytostatic activity of ferrocene-Cinchona hybrids.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Feb 01; Vol. 26 (3), pp. 946-949. Date of Electronic Publication: 2015 Dec 18. - Publication Year :
- 2016
-
Abstract
- Exploring copper(I)- and ruthenium(II)-catalyzed azide-alkyne cycloadditions and a Sonogashira protocol, novel cytostatic ferrocene-cinchona hybrids were synthetized displaying significant in vitro activity on HepG-2 and HT-29 cells. Preliminary SAR studies disclosed that compounds incorporating linkers with 1,2,3-triazole and chalchone residues can be considered as promising lead structures. According to the best of our knowledge this is the first letter on the incorporation of ferrocene nucleus in the reputed cinchona family via triazole and chalcone linkers with established pharmaceutical profile.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Alkynes chemistry
Azides chemistry
Catalysis
Cell Proliferation drug effects
Copper chemistry
Cycloaddition Reaction
Cytostatic Agents chemistry
Cytostatic Agents pharmacology
HT29 Cells
Hep G2 Cells
Humans
Metallocenes
Ruthenium chemistry
Structure-Activity Relationship
Cinchona chemistry
Cytostatic Agents chemical synthesis
Ferrous Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 26739780
- Full Text :
- https://doi.org/10.1016/j.bmcl.2015.12.059