Solid-State NMR of PEGylated Proteins.

Authors :: Ravera E
Ciambellotti S
Cerofolini L
Martelli T
Kozyreva T
Bernacchioni C
Giuntini S
Fragai M
Turano P
Luchinat C
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Feb 12; Vol. 55 (7), pp. 2446-9. Date of Electronic Publication: 2016 Jan 12.
Publication Year :: 2016
Abstract: PEGylated proteins are widely used in biomedicine but, in spite of their importance, no atomic-level information is available since they are generally resistant to structural characterization approaches. PEGylated proteins are shown here to yield highly resolved solid-state NMR spectra, which allows assessment of the structural integrity of proteins when PEGylated for therapeutic or diagnostic use.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)