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Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Feb 01; Vol. 26 (3), pp. 774-777. Date of Electronic Publication: 2015 Dec 29. - Publication Year :
- 2016
-
Abstract
- Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol-norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Bridged Bicyclo Compounds, Heterocyclic toxicity
Drug Carriers chemistry
Embryo, Nonmammalian drug effects
Hydrophobic and Hydrophilic Interactions
Liposomes chemistry
Medicine, Chinese Traditional
Particle Size
Resveratrol
Stilbenes toxicity
Zebrafish growth & development
Bridged Bicyclo Compounds, Heterocyclic chemistry
Nanoparticles chemistry
Stilbenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 26764188
- Full Text :
- https://doi.org/10.1016/j.bmcl.2015.12.099