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[Primary non-Hodgkin's lymphoma of the breast. A case report].
- Source :
-
Cirugia y cirujanos [Cir Cir] 2017 Jan - Feb; Vol. 85 (1), pp. 70-75. Date of Electronic Publication: 2016 Jan 06. - Publication Year :
- 2017
-
Abstract
- Background: Primary breast lymphomas, a rare subtype of non-Hodgkin's lymphoma, represent 0.04 to 0.5% of all breast cancers, 0.38 to 0.7% of all lymphomas, and 1.7 to 2.2% of extranodal lymphomas. The treatment choice is based on chemotherapy containing anthracycline and rituximab. Surgery is limited to being less invasive and only for diagnostic purposes. Radiotherapy has an important role as consolidation therapy, particularly in patients with negative nodes.<br />Clinical Case: A 70 year old woman with a breast nodule in the left upper outer quadrant, with slow growth, expansive, painless, and accompanied by skin changes, malaise, weight loss, fatigue, chill, and sweating. There was tissue replacement by the mammary gland tumour, skin changes due to invasion, and a 5cm axillary lymphadenopathy. The mammography showed skin thickening and a dense pattern of 80% of breast tissue replacement, and the lymphadenopathy with loss of radiolucent centre and soft tissue invasion. The biopsy confirmed a diffuse high grade large cell lymphoma. She received an Rituximab (R-CHOP) chemotherapy scheme and radiotherapy with tangential and supraclavicular and axillary fields. After completing the chemotherapy, the patient is on follow-up, and at 15 months she is alive without disease activity.<br />Conclusions: Primary lymphoma of the breast is a rare entity. Multimodal treatment with combined chemo-radiotherapy is the cornerstone. Surgery is reserved only for diagnostic purposes.<br /> (Copyright © 2015 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.)
- Subjects :
- Aged
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Breast Neoplasms drug therapy
Breast Neoplasms radiotherapy
Combined Modality Therapy
Cyclophosphamide administration & dosage
Diagnostic Errors
Doxorubicin administration & dosage
Female
Humans
Lymphoma, Large B-Cell, Diffuse drug therapy
Lymphoma, Large B-Cell, Diffuse radiotherapy
Mammography
Mastitis diagnosis
Prednisone administration & dosage
Remission Induction
Rituximab administration & dosage
Ultrasonography, Mammary
Vincristine administration & dosage
Breast Neoplasms diagnostic imaging
Lymphoma, Large B-Cell, Diffuse diagnostic imaging
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 2444-054X
- Volume :
- 85
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cirugia y cirujanos
- Publication Type :
- Academic Journal
- Accession number :
- 26769528
- Full Text :
- https://doi.org/10.1016/j.circir.2015.09.009