Increased body mass index associated with autonomic dysfunction in Parkinson's disease.

Authors :: Mochizuki H
Taniguchi A
Nakazato Y
Ishii N
Ebihara Y
Sugiyama T
Shiomi K
Nakazato M
Source :: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2016 Mar; Vol. 24, pp. 129-31. Date of Electronic Publication: 2016 Jan 09.
Publication Year :: 2016
Abstract: Background: The association between Parkinson's disease (PD) and body mass index (BMI) has not been established. In this study, we investigated the correlation between BMI and autonomic dysfunction in patients with PD.<br />Methods: Clinical features, BMI, cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy and the coefficient of variation of the electrocardiographic R-R interval (CVRR) were analyzed in 124 patients with PD who were naïve to anti-parkinsonian drugs.<br />Results: BMI was negatively correlated with early heart-to-mediastinum ratio and CVRR in patients with PD, regardless of disease duration and severity.<br />Conclusions: Autonomic dysfunction and BMI increase were associated with each other. Physicians should consider the possibility of autonomic dysfunction in PD patients with high BMI.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Subjects :: 3-Iodobenzylguanidine pharmacokinetics
Aged
Autonomic Nervous System Diseases diagnostic imaging
Female
Humans
Male
Middle Aged
Parkinson Disease diagnostic imaging
Radiopharmaceuticals pharmacokinetics
Retrospective Studies
Autonomic Nervous System Diseases etiology
Body Mass Index
Parkinson Disease complications

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