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Molecular cloning of the breakpoint region on chromosome 6 in cutaneous malignant melanoma: evidence for deletion in the c-myb locus and translocation of a segment of chromosome 12.
- Source :
-
Oncogene [Oncogene] 1989 Oct; Vol. 4 (10), pp. 1201-5. - Publication Year :
- 1989
-
Abstract
- Nonrandom involvement of chromosome 6 in cutaneous malignant melanoma have been noted by several investigators. Recently an alteration in the c-myb locus (6q22-23) has been identified by Southern analysis in the WM983A cell line which was derived from a primary melanoma of the vertical growth phase. In the present study, the nature of this rearrangement in the WM983A cell line has been further characterized by molecular cloning and nucleotide sequence analysis of the break-point region in the c-myb locus. The results of this investigation demonstrate that the rearrangement in the 6q22-23 region results in deletion of the 3'-end of the c-myb locus with the concomitant translocation of a portion of chromosome 12 to chromosome 6.
- Subjects :
- Base Sequence
Cloning, Molecular
Gene Rearrangement
Humans
Molecular Sequence Data
Proto-Oncogene Proteins c-myb
Tumor Cells, Cultured
Chromosome Deletion
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 6
Melanoma genetics
Proto-Oncogene Proteins genetics
Proto-Oncogenes
Skin Neoplasms genetics
Translocation, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0950-9232
- Volume :
- 4
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 2677917