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Development of IgG Mediated Antibody Dependent Cell-mediated Cytotoxicity (ADCC) in the Serum and Genital Mucosa of HIV Seroconverters.
- Source :
-
Journal of AIDS & clinical research [J AIDS Clin Res] 2015 Jul; Vol. 6 (7). Date of Electronic Publication: 2015 Jul 09. - Publication Year :
- 2015
-
Abstract
- Background: We measured antibody-dependent cell mediated cytotoxicity (ADCC) activity in serum and genital fluids of heterosexually exposed women during HIV seroconversion.<br />Methods: Plasma and cervico-vaginal lavage (CVL) fluid from 11 seroconverters (SC) were analyzed biannually from one year pre- to 6 year post-seroconversion using a <superscript>51</superscript> Cr-release assay to measure HIV-1 gp120 specific ADCC.<br />Results: No SC had significant HIV specific CVL ADCC activity before seroconversion or until 1.5 yr after seroconversion. One individual had a %Specific Release (SR) of 25.4 at 2 years, 26.7 at 3 years and 21.0 at 4 years after seroconversion in CVL. Another sample had 4.7% SR at 2 years, 5.3 at 3 years, 10.9 at 4 years, and 8.4 at 5 years after seroconversion in CVL. A third had no activity until 17% SR 5 years after seroconversion in CVL. A fourth showed activity of 36.5% SR at 6.5 years after seroconversion. Seven women had no ADCC activity in their CVL. Paired serum samples showed HIV specific ADCC activity prior to the appearance of CVL ADCC activity.<br />Conclusions: HIV specific ADCC activity in CVL rose 2 years after seroconversion; ADCC was present in the serum prior to this time. These data suggest that genital tract ADCC activity is not present until well after acute infection.
Details
- Language :
- English
- ISSN :
- 2155-6113
- Volume :
- 6
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of AIDS & clinical research
- Publication Type :
- Academic Journal
- Accession number :
- 26798561
- Full Text :
- https://doi.org/10.4172/2155-6113.1000479