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[A Case of Pathologically Complete Response of a Rectal Cancer after Preoperative Treatment with mFOLFOX6 and Radiation Therapy].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2015 Nov; Vol. 42 (12), pp. 1472-4. - Publication Year :
- 2015
-
Abstract
- A 60-year-old man who had bloody stools after sigmoid colonoscopy was admitted to our hospital. A digital examination and sigmoid colonoscopy showed a type 2 circular tumor at location Rb with incomplete mobility and tumor hemorrhage, and the result of a biopsy was moderately differentiated adenocarcinoma (tub2). Computed tomography and magnetic resonance imaging suggested a possibility of invasion of the primary rectal tumor to the sacrum. The clinical stage was cT4bN0M0H0P0, cStage Ⅱ, which is generally not treatable by surgery. Sigmoid colostomy was performed, and a central venous port was implanted. After a preoperative treatment consisting of 3 courses of mFOLFOX6 and radiation therapy, the clinical stage changed to ycT2N0M0H0P0, ycStageⅠ. Super-low anterior resection and covering ileostomy were performed 46 days after the preoperative treatment. A pathological examination revealed no residual cancer cells in the primary lesion and lymph node (Grade 3, pCR). The patient has been disease-free for 4 years and 9 months after the operation.
- Subjects :
- Adenocarcinoma radiotherapy
Adenocarcinoma surgery
Combined Modality Therapy
Fluorouracil therapeutic use
Humans
Leucovorin therapeutic use
Magnetic Resonance Imaging
Male
Middle Aged
Organoplatinum Compounds therapeutic use
Rectal Neoplasms radiotherapy
Rectal Neoplasms surgery
Remission Induction
Tomography, X-Ray Computed
Adenocarcinoma drug therapy
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Rectal Neoplasms drug therapy
Rectal Neoplasms pathology
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 42
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 26805067